My postdoctoral research is focused to develop a patient-specific, induced pluripotent stem cells (iPSCs) based in-vitro platform for Non-Alcoholic Steatohepatitis (NASH) disease modelling and examine the effect of extracellular matrix stiffness and microfluidic flow on the hepatic lipid metabolism in NASH. This study would enhance the physiological relevance for disease modeling and may provide a powerful non-invasive in vitro platform to study the disease pathogenesis and novel drug development. I am also working to generate bioartificial liver tissues, using iPSC-derived hepatic progenitors and acellular bio-scaffolds. In the line to generate bioartificial liver, I am also working to generate physiologically functional liver tissues/organoids from patient-derived iPSC. Our long-term goal is to generate liver tissues in the laboratory that can replace or repair the failing liver and abrogate the longer waiting times associated with organ transplantation.
